DNA Methylation: Superior or Subordinate in the Epigenetic Hierarchy?
نویسندگان
چکیده
منابع مشابه
Epigenetic Hierarchy within the MAGEA1 Cancer-Germline Gene: Promoter DNA Methylation Dictates Local Histone Modifications
Gene MAGEA1 belongs to a group of human germline-specific genes that rely on DNA methylation for repression in somatic tissues. Many of these genes, termed cancer-germline (CG) genes, become demethylated and activated in a wide variety of tumors, where they encode tumor-specific antigens. The process leading to DNA demethylation of CG genes in tumors remains unclear. Previous data suggested tha...
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The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional activation or repression by recognizing the sequence of DNA bases in their promoter regions. Interaction of these factors with their cognate seque...
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Cite this article: Yamada N, Yonezawa S (2013) Understanding Epigenetic Status: DNA Methylation and Cancer. J Cancer Biol Res 1(2): 1008. *Corresponding author Norishige Yamada, Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan, Tel: +81-99275-5270; Fax: +81-99-265-7235; E-mail: ya...
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During embryonic development, cell type-specific transcription factors promote cell identities, while epigenetic modifications are thought to contribute to maintain these cell fates. Our understanding of how genetic and epigenetic modes of regulation work together to establish and maintain cellular identity is still limited, however. Here, we show that DNA methyltransferase 3bb.1 (dnmt3bb.1) is...
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Why some patients develop limband life-saving collaterals but others do not constitutes one of the great challenges that face patients with peripheral vascular and coronary artery disease. A longstanding goal in vascular disease is the establishment of therapies that enhance angiogenesis in compromised tissue beds. To achieve this goal, however, it is essential to define and understand the unde...
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ژورنال
عنوان ژورنال: Genes & Cancer
سال: 2011
ISSN: 1947-6019,1947-6027
DOI: 10.1177/1947601910393957